Deutsche Bank will cut 18,000 jobs over the next three years as part a radical reorganisation of the German bank.
The struggling lender also announced that it expects to report losses of €2.8bn in the second quarter to pay for the shake-up of the business.
Deutsche Bank is yet to specify exactly where jobs will be lost.
But it said it intends to completely exit activities related to the buying and selling of shares, much of which is conducted in London and New York.
That will help it meet a target to make savings of €17bn by 2022.
"Today we have announced the most fundamental transformation of Deutsche Bank in decades," chief executive Christian Sewing said.
"This is a restart for Deutsche Bank... In refocusing the bank around our clients, we are returning to our roots and to what once made us one of the leading banks in the world," he said.
The reorganisation of the business follows the failure of merger talks with rival Commerzbank in April.
The German government had supported the tie-up, hoping it would create a national champion in the banking industry.
However, both banks concluded that the deal was too risky, fearing the costs of combining might have outweighed the benefits.
Deutsche Bank has been struggling for years with the decline of its investment bank and has made several attempts to revamp its business.
The latest plan will be the most ambitious so far and it has already prompted the resignation of one top executive.
On Friday, the bank announced that its head of investment banking, Garth Ritchie, was leaving.
Under the plan, a new unit is being created which will house assets that belong to businesses it no longer wants.
It estimates those assets to be worth €74bn.