More than 300 jobs are at risk after a baggage handling firm said it was ceasing operations at Manchester Airport following the collapse of Thomas Cook.
Sweden-based Aviator said the travel firm accounted for 70% of its work at the airport and that its collapse meant it could no longer operate as a viable business at the site.
The decision affects 351 jobs and trade union Unite warned further job losses would mount up as ground handlers at other sites were also lining up potential redundancies.
It is the latest knock-on effect of Thomas Cook’s collapse which has already cost 9,000 UK employees their jobs.
Aviator said the decision was "another unfortunate outcome stemming from Thomas Cook’s recent liquidation" and that its last day of operations in Manchester would be on 22 October.
"Thomas Cook was our largest customer, accounted for approximately 70% of our service in Manchester and despite our efforts over the last two weeks we have concluded that we cannot operate as a viable business supporting our only remaining customers," the company said.
"We are not the only business to be affected negatively by the Thomas Cook situation.
"This is an unfortunate circumstance that we deeply regret."
The company said it was seeking to transfer as many workers as possible to other ground services operators and airlines at the airport.
Unite national officer Oliver Richardson said: "The scale of additional job losses in the supply chain will significantly add to the number of losses in the airline itself."
The union has accused the government of "economic vandalism" for declining to provide a £200m funding lifeline to help Thomas Cook stay afloat.
The company’s collapse late last month left 150,000 holidaymakers needing to be brought back home in what was Britain’s largest ever peacetime repatriation — which concluded at the start of this week.
It also left 360,000 customers with future holiday bookings owed refunds.
A website set up by the Civil Aviation Authority (CAA) to process the claims struggled to cope with a surge of applications when it was set up on Monday — with 60,000 received on the day.
Meanwhile there were warnings about a fake refund website set up to attempt to scam Thomas Cook customers out of their personal information.
On Tuesday, the CAA said it had taken "urgent action" in response to the suspected fraudulent activity and urged customers only to make claims through its official dedicated website.